eLife1d
Balancing safety and efficiency in human decision making
The safety-efficiency dilemma describes the problem of maintaining safety during efficient exploration and is a special case of the exploration-exploitation dilemma in the face of potential dangers.
eLife1d
Xist RNA binds select autosomal genes and depends on Repeat B to regulate their expression
This valuable study addresses potential roles of the master regulator of X chromosome inactivation, the Xist long non-coding RNA, in autosomal gene regulation. Using data from mouse cells, the authors ...
eLife3d
Range geographies, not functional traits, explain convergent range and phenology shifts under climate change
This article presents valuable findings on the impact of climate change on odonates, integrating phenological and range shifts to broaden our understanding of biodiversity change. The study leverages ...
eLife3d
Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis
The most common primary malignancy of the liver, hepatocellular carcinoma (HCC), is a heterogeneous tumor entity with high metastatic potential and complex pathophysiology. Increasing evidence ...
eLife3d
Vole Parenting: A fine line between attack and care
Oxytocin neuron projections from two brain regions involved in parental care regulate both parental care and infanticidal behaviors in virgin mandarin voles.
eLife3d
Rabphilin-3A negatively regulates neuropeptide release, through its SNAP25 interaction
Neuropeptides and neurotrophins are stored in and released from dense core vesicles (DCVs). While DCVs and synaptic vesicles (SVs) share fundamental SNARE/SM proteins for exocytosis, a detailed ...
eLife3d
Intestinal microbiome dysbiosis increases Mycobacteria pulmonary colonization in mice by regulating the Nos2-associated pathways
Department of Tuberculosis, The First Affiliated Hospital of Xinxiang Medical University, China; Department of Pathogenic Biology, School of Basic Medical Science, Xinxiang Medical University, China; ...
eLife3d
Hypothalamic representation of the imminence of predator threat detected by the vomeronasal organ in mice
Animals in natural environments need to identify predator-associated cues and respond with the appropriate behavioral response to survive. In rodents, some chemical cues produced by predators (e.g., ...
eLife3d
Negative regulation of APC/C activation by MAPK-mediated attenuation of Cdc20 Slp1 under stress
State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, China; Institute of Life Sciences, College of Biological Science and ...
eLife3d
Peer review process
Version of Record: This is the final version of the article. This work sought to demonstrate that gut microbiota dysbiosis may promote the colonization of mycobacteria, and they tried to prove that ...
eLife3d
Rabphilin-3A negatively regulates neuropeptide release, through its SNAP25 interaction
The molecular mechanisms that mediate the regulated exocytosis of neuropeptides and neurotrophins from neurons via large dense-core vesicles (LDCVs) are still incompletely understood. Motivated by ...