eLife1d
Synapse weakening-induced caspase-3 activity confers specificity to microglia-mediated synapse elimination
This study presents an important finding on the involvement of a Caspase 3-dependent pathway in the elimination of synapses for retinogeniculate circuit refinement and eye-specific territory ...
eLife1d
Balancing safety and efficiency in human decision making
The safety-efficiency dilemma describes the problem of maintaining safety during efficient exploration and is a special case of the exploration-exploitation dilemma in the face of potential dangers.
eLife1d
Direct observation of the neural computations underlying a single decision
Simultaneous recording from many neurons in macaque lateral intraparietal area reveals the elusive drift-diffusion signal, long suspected to underlie individual perceptual decisions and response times ...
eLife1d
Xist RNA binds select autosomal genes and depends on Repeat B to regulate their expression
This valuable study addresses potential roles of the master regulator of X chromosome inactivation, the Xist long non-coding RNA, in autosomal gene regulation. Using data from mouse cells, the authors ...
eLife5d
A host enzyme reduces non-alcoholic fatty liver disease by inactivating intestinal lipopolysaccharide
The findings are significant for the liver research community and others interested in the gut-liver axis. (A) AOAH cleaves the two piggyback fatty acyl chains from the lipid A moiety, inactivating ...
eLife3d
Rabphilin-3A negatively regulates neuropeptide release, through its SNAP25 interaction
Live imaging at single-vesicle resolution reveals rabphilin-3A as the first identified negative regulator of neuropeptide release in mammalian neurons.
eLife3d
Range geographies, not functional traits, explain convergent range and phenology shifts under climate change
This article presents valuable findings on the impact of climate change on odonates, integrating phenological and range shifts to broaden our understanding of biodiversity change. The study leverages ...
eLife3d
Vole Parenting: A fine line between attack and care
Oxytocin neuron projections from two brain regions involved in parental care regulate both parental care and infanticidal behaviors in virgin mandarin voles.
eLife4d
Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism
Program for Cancer and Cell Biology, Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences; Peking University International Cancer Institute; and State Key Laboratory ...
eLife5d
Amidase and Lysozyme Dual Functions in TseP Reveal a New Family of Chimeric Effectors in the Type VI Secretion System
State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, ...
eLife4d
Arthropods dominate plant litter decomposition in drylands
An analysis of leaf litter breakdown in climatically diverse habitats shows that decomposition by larger invertebrates dominates in hot, dry regions and warmer seasons.
eLife5d
Maternal behavior influences vocal practice and learning processes in the greater sac-winged bat
Smithsonian Tropical Research Institute, Luis Clement Avenue, Bldg. 401 Tupper, Balboa Ancon, Republic of Panama ...