In 1974, Brouet and colleagues described a classification system, which is still used today, based on the isotype (or isotypes) of immunoglobulins constituting the cryoglobulinemia: type I ...

Kidney transplantation from donors with human immunodeficiency virus (HIV) to recipients with HIV is an emerging practice. It has been performed since 2016 under the U.S. congressional HIV Organ ...

Combination chemotherapy has been the standard treatment for advanced-stage Hodgkin’s lymphoma for decades. Chemotherapy backbones differ worldwide, with doxorubicin, bleomycin, vinblastine, and ...

Whether stereotactic body radiotherapy (SBRT) is noninferior to conventionally or moderately hypofractionated regimens with respect to biochemical or clinical failure in patients with localized ...

In this Double Take video from the New England Journal of Medicine, Dr. Nathaniel Morris (University of California San Francisco) examines the complex relationship between mental health and ...

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Cerebral adrenoleukodystrophy is a severe form of X-linked adrenoleukodystrophy characterized by white-matter disease, loss of neurologic function, and early death. Elivaldogene autotemcel (eli ...

Hairy-cell leukemia (HCL) is a rare, indolent neoplasm of mature B cells with hairlike surface projections that circulate in the blood and preferentially infiltrate the bone marrow and spleen.

Treatments for Dupuytren’s contracture include limited fasciectomy and collagenase injection. Comparisons of the effectiveness of these treatments have been limited. We performed an unblinded ...

Dr. Danielle C. Crabtree (Medicine): A 37-year-old man was admitted to this hospital because of fever, myalgia, jaundice, and hypoxemia. The patient had been healthy until 9 days before this ...

Gene therapy with elivaldogene autotemcel (eli-cel) consisting of autologous CD34+ cells transduced with lentiviral vector containing ABCD1 complementary DNA (Lenti-D ...

More than 30 years ago, the first transplantation with autologous hematopoietic stem cells modified with integrated murine retroviral vectors carrying potentially therapeutic genes was performed ...